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Even modifications to hyaluronan, through crosslinking with bis thio-polyethylene glycol solution and albumin, are under investigation in safety trials for intra-discal delivery of ex vivo-expanded autologous IVD cells (NCT01640457, (101))

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TNF regulates cellular NAD+ metabolism in primary macrophages [PMID: 16516847] Laboratory literature summary: TNF regulates cellular NAD+ metabolism in primary macrophages