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Figure 1 The core of lipid peroxidation is the peroxidation chain reaction of polyunsaturated fatty acid-containing phospholipids (22)

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However, Cas9-induced double-stranded DNA breaks can cause cytotoxicity, influencing proliferation and differentiation decisions 33,34 , whereas acquired genetic and epigenetic variation in source iPS cells 35,36 , and patterning biases 37 and cell stress 38 during differentiation, can influence cell-type fidelity and fate specification in organoid models