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These include transcriptional regulation by transcription factors, epigenetic regulators, and post-transcriptional regulatory mechanisms such as tuning its mRNA levels, subcellular localization, protein stability, and transporter protein activity ( 2.2.1 Transcriptional regulation of SLC7A11 by transcriptional factors SLC7A11 is induced to be expressed under diverse stress conditions, including oxidative stress, amino acid starvation, metabolic stress, and genotoxic stress, contributing to maintaining redox homeostasis and supporting cells alive under stress conditions ( Furthermore, the expression of SLC7A11 can also be transcriptionally repressed ( In summary, SLC7A11 expression is repressed by ATF3 and p53 under basal conditions, whereas various stress conditions promote SLC7A11 transcription partly via ATF4 or NRF2
