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Given their resistance to even prolonged erastin treatment or SLC7A11 KO, these results also suggest that latency III cells have alternative means of meeting cysteine demand, and further suggest that they may utilize non-GPX4 pathways for lipid ROS detoxification (Fig

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Insufficient MRE11a activity leads to mitochondrial DNA instability, mtDNA leakage into the cytoplasm, and subsequent inflammasome activation [96]

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