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However, we discovered that these peptides are also functional substrates of transglutaminase (TGM) 2, also called tissue TGM, and that structural disruption of the epidermis was repaired when these tetravalent peptides were applied topically as cross-linking substrates, regardless of possible interaction with MGL1 or MGL2

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Rg1 can promote the release of acetylcholine, a neurotransmitter maintaining critical cognitive functions, to enhance the cholinergic system, further bolstering cognitive capability (Singh et al., 2024