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Since increased activation of AP-1 by arsenite could be inhibited by either treating cells with MAP kinase Erk kinase (MEK)1 inhibitor or overexpression of dominant-negative protein kinase C α (PKCα), this induction appears to occur through activation of mitogen-activated protein (MAP) kinases and PKC

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20,21,25,26,115,116 The extent of the effects themselves can vary simply as a function of particle size

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