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doi: 10.1111/j.1469-7793.2001.00937.x

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Daniel Drucker at the Lunenfeld-Tanenbaum Research Institute and University of Toronto — one of the world's leading GLP-1 researchers — co-authored a comprehensive 2025 review in the Journal of Clinical Investigation documenting anti-inflammatory GLP-1 mechanisms across nearly every organ system, from liver to kidney to lung to nervous system.11 One particularly relevant finding for aging adults: in animal models, semaglutide and exenatide reduce plasma TNF-α levels triggered by TLR1, TLR2, TLR4, TLR5, and TLR9 agonists — but this effect requires GLP-1R expression in brain neurons, and it depends on intact α1-adrenergic and δ-opioid receptor signaling