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Intriguingly, NNT silencing also promoted mitochondrial membrane hyperpolarization, increased oxygen consumption and ATP production, and diminished lactate production, implying a metabolic shift from glycolysis to mitochondrial OXPHOS to correct the accumulation of NADH in these cells
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Regulatory approvals for somapacitan-beco and somatrogon-ghla have confirmed the viability of long-acting products in the United States, and several other molecules are in the advanced development pipeline